Multiple mode of binding of phencyclidines: High affinity association between phencyclidine receptors in rat brain and a monovalent ion-sensitive polypeptide
作者： Rachel Haring , Yoel Kloog , Na-ava harshak-Felixbrodt , Mordechai Sokolovsky
DOI: 10.1016/0006-291X(87)90303-2
关键词: Hippocampus 、 Cerebrum 、 Phencyclidine 、 Ligand (biochemistry) 、 Chemistry 、 Stereochemistry 、 Piperidine 、 Binding site 、 Receptor 、 In vitro 、 Biophysics 、 Cell biology 、 Biochemistry 、 Molecular biology
摘要: Two populations of phencyclidine (PCP) binding sites are shown to exist in the rat brain: a high-affinity monovalent ion-sensitive site (Kd 10-14 nM for [3H]TCP, [3H]N-[1-(2-thienyl)cyclohexyl]piperidine), which exists both frontal cortex and hippocampus, lower affinity 80-130 [3H]TCP) is found hippocampus but not cortex. The nature interactions between ion-binding high PCP receptors depend on ligand structure (PCP or TCP) ion involved (K' Na'). associated with an Mr 90,000 polypeptide whose labeling by [3H]azido selectively inhibited ions.
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