Autoradiographic distribution of [3H]dexoxadrol (a phencyclidine-related ligand) binding sites in rat and human brain
作者： Carmencita Pilapil , Patricia Contreras , Thomas L. O'Donohue , Remi Quirion
DOI: 10.1016/0304-3940(85)90431-8
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摘要: [3H]dexoxadrol, a dissociative anesthetic, binds with high affinity to specific sites in rat brain (membrane binding and light microscopic autoradiography). Various phencyclidine (PCP) analogues compete for [3H]dexoxadrol slightly different manner than against [3H]PCP sites. As binding, are highly concentrated regions such as the cortex hippocampus. However, other areas hypothalamus enriched only This suggests that PCP-related certain but not others. In human forebrain, distributed mainly found caudate, putamen cortex.
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sci-hub.se 参考文章(24)
Edward F. Domino, Neurobiology of Phencyclidine (Sernyl), A Drug With An Unusual Spectrum of Pharmacological Activity International Review of Neurobiology. ,vol. 6, pp. 303- 347 ,(1964) , 10.1016/S0074-7742(08)60772-2
J H Woods, S Herling, R E Solomon, Discriminative stimulus effects of dextrorphan in pigeons. Journal of Pharmacology and Experimental Therapeutics. ,vol. 227, pp. 723- 731 ,(1983)
T.F. Murray, M.E. Leid, Interaction of dextrorotatory opioids with phencyclidine recognition sites in rat brain membranes Life Sciences. ,vol. 34, pp. 1899- 1911 ,(1984) , 10.1016/0024-3205(84)90121-8
Remi Quirion, Debora A. DiMaggio, Edward D. French, Patricia C. Contreras, Joseph Shiloach, Candace B. Pert, Hilleary Everist, Agu Pert, Thomas L. O'Donohue, Evidence for an endogenous peptide ligand for the phencyclidine receptor Peptides. ,vol. 5, pp. 967- 973 ,(1984) , 10.1016/0196-9781(84)90124-4
Jacques Vignon, Robert Chicheportiche, Michèle Chicheportiche, Jean-Marc Kamenka, Patrick Geneste, Michel Lazdunski, [3H]TCP: a new tool with high affinity for the PCP receptor in rat brain. Brain Research. ,vol. 280, pp. 194- 197 ,(1983) , 10.1016/0006-8993(83)91193-9
RÉMI QUIRION, CATHERINE CSONKA, PIERRE ETIENNE, N. P. V. NAIR, YVES ROBITAILLE, PIERRETTE GAUDREAU, Autoradiographic Localization of Cholecystokinin Receptors in Human Brain Annals of the New York Academy of Sciences. ,vol. 448, pp. 624- 626 ,(1985) , 10.1111/J.1749-6632.1985.TB29969.X
Yasuhiko Hosoya, Matsuo Matsushita, Brainstem projections from the lateral hypothalamic area in the rat, as studied with autoradiography Neuroscience Letters. ,vol. 24, pp. 111- 116 ,(1981) , 10.1016/0304-3940(81)90232-9
A POLING, F WHITE, J APPEL, Discriminative stimulus properties of phencyclidine. Neuropharmacology. ,vol. 18, pp. 459- 463 ,(1979) , 10.1016/0028-3908(79)90070-4
ROY D. WILSON, DANIEL L. TRABER, ERNEST BARRATT, DANIEL L. CRESON, RICHARD C. SCHMITT, CHARLES R. ALLEN, Evaluation of CL-1848C: a new dissociative anesthetic in normal human volunteers. Anesthesia & Analgesia. ,vol. 49, pp. 236- 241 ,(1970) , 10.1213/00000539-197003000-00011
Stephen C. Berry, Nabil A. Anis, David Lodge, The effect of the dioxolanes on amino acid induced excitation in the mammalian spinal cord Brain Research. ,vol. 307, pp. 85- 90 ,(1984) , 10.1016/0006-8993(84)90463-3