Formoterol May Activate Rat Muscle Regeneration During Cancer Cachexia
作者： Elisabet Ametller , Sílvia Busquets , Gemma Fuster , Maria T. Figueras , Mireia Olivan
DOI: 10.5640/INSC.01011
关键词: Formoterol 、 Internal medicine 、 Bupivacaine 、 Muscle regeneration 、 Gene expression 、 Messenger RNA 、 Biology 、 MyoD 、 Myogenin 、 Endocrinology 、 Agonist
摘要: PURPOSE: The development of cancer cachexia is the most common manifestation advanced malignant disease. METHOD: effects on muscle regeneration β2�adrenoceptor agonist formoterol (0.3 mg/kg) were tested in cachectic tumourbearing rats (Yoshida AH�130 ascit es hepatoma). RESULTS: Administration results a significant increase mass and protein content tibialis tumourbearin grats. This associated with decreased myogenin mRNA together an increased Pax�7 gene expression. Bupivacaine treatment by local injection important reduction weight increases Pax�7, MyoD Formoterol bupivacainetreated decreases content, suggesting that this β2�agonist favouring stimulating proliferation satellite cells. Altogether, data reinforce potential role wasting diseases.
sci-hub.st 参考文章(52)
Panorea K. Politi, Sophia Havaki, Panagiota Manta, George Lyritis, Bupivacaine-induced Regeneration of Rat Soleus Muscle: Ultrastructural and Immunohistochemical Aspects Ultrastructural Pathology. ,vol. 30, pp. 461- 469 ,(2006) , 10.1080/01913120600854434
Leon J. Spicer, Pauline Y. Aad, Dustin T. Allen, Sabine Mazerbourg, Anita H. Payne, Aaron J. Hsueh, Growth Differentiation Factor 9 (GDF9) Stimulates Proliferation and Inhibits Steroidogenesis by Bovine Theca Cells: Influence of Follicle Size on Responses to GDF9 Biology of Reproduction. ,vol. 78, pp. 243- 253 ,(2008) , 10.1095/BIOLREPROD.107.063446
Ursula A. Vitt, Sabine Mazerbourg, Cynthia Klein, Aaron J.W. Hsueh, Bone Morphogenetic Protein Receptor Type II Is a Receptor for Growth Differentiation Factor-9 Biology of Reproduction. ,vol. 67, pp. 473- 480 ,(2002) , 10.1095/BIOLREPROD67.2.473
Sushma Sharma, Asha Garg, Surender S. Katoch, Histological evidences of reparative and regenerative effects of beta-adrenoceptor agonists, clenbuterol and isoproterenol, in denervated rat skeletal muscle. Indian Journal of Experimental Biology. ,vol. 44, pp. 448- 458 ,(2006)
W DeWys, Management of cancer cachexia. Seminars in Oncology. ,vol. 12, pp. 452- 460 ,(1985)
A L Grant, W G Helferich, R A Merkel, W G Bergen, Effects of phenethanolamines and propranolol on the proliferation of cultured chick breast muscle satellite cells. Journal of Animal Science. ,vol. 68, pp. 652- 658 ,(1990) , 10.2527/1990.683652X
G P Anderson, Pharmacology of formoterol: an innovative bronchodilator. Agents and actions. ,vol. 34, pp. 97- 115 ,(1991)
M.J. STOCK, NANCY J. ROTHWELL, 16 – EFFECTS OF β-ADRENERGIC AGONISTS ON METABOLISM AND BODY COMPOSITION Control and Manipulation of Animal Growth#R##N#Proceedings of Previous Easter Schools in Agricultural Science. pp. 249- 257 ,(1986) , 10.1016/B978-0-407-00422-1.50021-1
H J Mersmann, Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action Journal of Animal Science. ,vol. 76, pp. 160- 172 ,(1998) , 10.2527/1998.761160X
Y T Yang, M A McElligott, Multiple actions of beta-adrenergic agonists on skeletal muscle and adipose tissue. Biochemical Journal. ,vol. 261, pp. 1- 10 ,(1989) , 10.1042/BJ2610001