Associations between cytokine receptor polymorphisms and variability in laboratory immune parameters in normal humans
作者： Lianbin Xiang , Okan U. Elci , Kristina E. Rehm , Gailen D. Marshall
DOI: 10.1016/J.HUMIMM.2013.09.007
关键词: Immune system 、 SNP array 、 Genetics 、 Biology 、 Cytokine 、 Single-nucleotide polymorphism 、 Allele 、 Immunology 、 Minor allele frequency 、 Receptor 、 Cytokine receptor 、 Immunology and Allergy 、 General Medicine
摘要: In every study involving human immune parameters, large inter-subject variability occurs which can make interpretation of results difficult. The aim this was to evaluate whether genetic variants in cytokine receptors could associate with laboratory measures. A total 207 normal volunteers were recruited study. Immunoregulatory profiles measured by flow cytometry and genotyping assays performed allelic discrimination real-time PCR. categorized according various single nucleotide polymorphisms (SNPs) including T-56C G-611A IFN-γ receptor 1 (IFNGR1); Q64R IFNGR2; Ile50Val, Q576R S503P IL4R. Results reveal that Th1 levels significantly higher the heterozygous IFNGR1 polymorphism (minor allele) compared wild-type (WT, major (p = 0.006). For IL4R, Th1/Th2 ratio lower for homozygous SNP (Arg/Arg) WT (Gln/Gln) 0.035). addition, significant interaction effects demographic characteristics on SNP-immune parameter associations reported as well. We conclude might Approach analysis be useful categorizing baseline responses more accurately clinical data.
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sci-hub.se 参考文章(44)
Hiromichi Mitsuyasu, Kenji Izuhara, Xiao-Quan Mao, Pei-Song Gao, Yojiro Arinobu, Tadao Enomoto, Mitsuru Kawai, Sei Sasaki, Yasuhiro Dake, Naotaka Hamasaki, Taro Shirakawa, Julian M. Hopkin, Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma. Nature Genetics. ,vol. 19, pp. 119- 120 ,(1998) , 10.1038/472
Susanne Kruse, Sandra Braun, Klaus A Deichmann, Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain. Respiratory Research. ,vol. 3, pp. 24- 24 ,(2002) , 10.1186/RR174
M Kondo, T Takeshita, N Ishii, M Nakamura, S Watanabe, K Arai, K Sugamura, Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science. ,vol. 262, pp. 1874- 1877 ,(1993) , 10.1126/SCIENCE.8266076
Sandeep K. Agarwal, Gailen D. Marshall, β-Adrenergic modulation of human type-1/type-2 cytokine balance The Journal of Allergy and Clinical Immunology. ,vol. 105, pp. 91- 98 ,(2000) , 10.1016/S0091-6749(00)90183-0
Tim R. Mosmann, James J. Kobie, F. Eun-Hyung Lee, Sally A. Quataert, T helper cytokine patterns: defined subsets, random expression, and external modulation Immunologic Research. ,vol. 45, pp. 173- 184 ,(2009) , 10.1007/S12026-009-8098-5
Thorsten Thye, Gerd D. Burchard, Manfred Nilius, Bertram Müller-Myhsok, Rolf D. Horstmann, Genomewide Linkage Analysis Identifies Polymorphism in the Human Interferon-γ Receptor Affecting Helicobacter pylori Infection American Journal of Human Genetics. ,vol. 72, pp. 448- 453 ,(2003) , 10.1086/367714
KRUSE, JAPHA, TEDNER, SPARHOLT, FORSTER, KUEHR, DEICHMANN, The polymorphisms S503P and Q576R in the interleukin-4 receptor α gene are associated with atopy and influence the signal transduction Immunology. ,vol. 96, pp. 365- 371 ,(1999) , 10.1046/J.1365-2567.1999.00705.X
Oliver Koch, Agnes Awomoyi, Stanley Usen, Muminatou Jallow, Anna Richardson, Jeremy Hull, Margaret Pinder, Melanie Newport, Dominic Kwiatkowski, IFNGR1 Gene Promoter Polymorphisms and Susceptibility to Cerebral Malaria The Journal of Infectious Diseases. ,vol. 185, pp. 1684- 1687 ,(2002) , 10.1086/340516
H. M. Schrijver, T. Hooper-van Veen, M. J. van Belzen, J. B. A. Crusius, A. S. Pena, F. Barkhof, C. H. Polman, B. M. J. Uitdehaag, Polymorphisms in the genes encoding interferon-gamma and interferon-gamma receptors in multiple sclerosis. European Journal of Immunogenetics. ,vol. 31, pp. 133- 140 ,(2004) , 10.1111/J.1365-2370.2004.00456.X
Sergio D Rosenzweig, Alejandro A Schäffer, Li Ding, Rachel Sullivan, Balasz Enyedi, Jae-Joon Yim, James L Cook, James M Musser, Steven M Holland, Interferon-γ receptor 1 promoter polymorphisms: population distribution and functional implications Clinical Immunology. ,vol. 112, pp. 113- 119 ,(2004) , 10.1016/J.CLIM.2004.03.018