Relation between infarct size and left ventricular performance assessed in patients with first acute myocardial infarction randomized to intracoronary thrombolytic therapy or to conventional treatment.

摘要: Reperfusion of ischemic myocardium has been reported to increase the cumulative creatine klnase activity in plasma per gram Infarcted as assessed with method Shell et al. In an attempt find out whether infarct size assessment using Witteveen al was affected by reperfusion, relation between enzymatic analyzed Witteveen's and left ventricular (LV) function parameters 266 patients first acute myocardial infarction randomized Intracoronary thrombolysis (n = 134) or conventional therapy 132). Compared allocated therapy, intracoronary had smaller 29% (p < 0.001), LV end-diastolic end-systolic volume indexes 10% 0.05) 20% 0.005), respectively, higher ejection fraction (55 ± 1 % vs 49 %; p 0.001). The beneficial effects thrombolytic on performance were closely associated thromboiysis-induced limitation size. dependence from volume, not different 2 groups. It concluded that is influenced presence reperfusion. Therefore, this recommended for trials recanalization infarction.