Role of the metabotropic glutamate receptor subtype 1 in the harmaline-induced tremor in rats.
作者： Wacław Kolasiewicz , Katarzyna Kuter , Jadwiga Wardas , Krystyna Ossowska
DOI: 10.1007/S00702-009-0254-5
关键词: Glutamate receptor 、 Metabotropic glutamate receptor 、 Metabotropic receptor 、 Cerebellum 、 Harmaline 、 Metabotropic glutamate receptor 1 、 Inhibitory postsynaptic potential 、 Chemistry 、 Ataxia 、 Pharmacology
摘要: The present study shows that JNJ 16259685—a selective antagonist of glutamate metabotropic receptor subtype 1 (mGluR1) injected in doses 0.16 and 0.32 mg/kg sc strongly enhances tremor forelimbs, head trunk, hypolocomotion, ataxia induced by harmaline (7.5 mg/kg ip) rats. 16259685 inhibited locomotor exploratory activity per se. These results may suggest an inhibitory influence mGluR1 on the harmaline-induced motor disturbances.
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