High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma

摘要: P21 protein (Cdc42/Rac)-activated kinase 7 (PAK7) can promote neurite outgrowth, induce microtubule stabilization, and activate cell survival signaling pathways. PAK7 expression was found to increase with colon carcinoma progression, but the prognostic value, clinical significance, underlying mechanisms have not been explored. In my study, of up-related at both transcriptional translational levels in tumors compared that adjacent normal tissue. Patients PAK7-positive had a lower rate overall (OS) metastasis-free (MFS) (log-rank test, P < 0.001). A Cox proportional hazards model showed an independent factor for OS (hazard ration [HR], 2.08; 95% confidence interval [CI], 1.16-3.73; = 0.004) MFS (HR, 2.88; CI, 1.53-5.42; 0.001) patients cancer. were over-expressing experienced metastasis, died within significantly shorter time after surgery (P Knockdown by specific short hairpin RNA (shRNA) suppressed progression epithelial mesechymal transition (EMT), migration, invasion cancer cells vitro tumor growth vivo. However, overexpression promoted these processes. These findings indicate aberrant is associated occurrence metastasis poor outcomes human promoting EMT, assessment might be helpful predicting prognostication