Anti-angiogenic treatment strategies for malignant brain tumors.

摘要: The use of angiogenesis inhibitors may offer novel strategies in brain tumor therapy. In contrast to traditional cancer treatments that attack cells directly, target at the formation tumor-feeding blood vessels provide continuous supply nutrients and oxygen. With respect therapy, display unique features are unknown conventional chemotherapeutic agents. most important independence blood-brain barrier, cell type specificity, reduced resistance. Malignant tumors, especially malignant gliomas, among vascularized tumors known. Despite multimodal therapeutic approaches, prognosis remains dismal. Thus, be highly effective drugs against these tumors. a clinical setting, they could applied treatment multiple or postsurgically as an adjuvant therapy prevent recurrence. This article provides overview current anti-angiogenic with emphasis on substances already trials candidate for trials. cellular molecular basis is reviewed.