Pathologic Human Vitreous Promotes Contraction by Fibroblasts

摘要: Objectives: To establish and quantify the presence of contraction-stimulating activity in pathologic vitreous correlate this with clinical presentation outcome, especially proliferative vitreoretinopathy. Methods: Contraction-stimulating collected during surgery was quantified a tissue culture assay using fibroblasts as target cells. The each sample correlated patient history, presentation, risk factors, disease, postoperative proliferation. Results: Pathologic contained measurable quantities stimulated contraction vitro, elevated activities samples from patients vitreoretinopathy, epimacular proliferation, retinal detachment, defects, pigmented cells vitreous, hemorrhage, or uveitis. Patients proliferation had significantly mean activities. Conclusions: Levels some factors for development vitreoretinopathy may ultimately be useful assessment disease severity prediction