Antifertility effect of Iranian neem seed alcoholic extract on epididymal sperm of mice

摘要: Background: About 90% of the world’s contraceptive users are women. This gender-based usage has occurred due to emphasis family planning programs and contraception research. Condom, vasectomy withdrawal only male devices available with less assurance for men. For new have an impact, they must be acceptable both men women, as well effective. A hormonal method will likely come market within next few years. It is necessary use biologically active botanical substances or fertility-regulating agents plant origin which ecofriendly. Objectives: The epididymis a site can exploited without undue side effects. was therefore interest investigate effect ecofriendly plants such Azadirchta Indica (neem) seed alcoholic extract efficient competent on mouse epididymis. Materials Methods: In this experimental case control study sixty adult healthy mice divided into two groups 40 20 treated group. group administered by Iranian Botanical Azadirachta extract, cultivated at Dashteh Moghan (Ardabil province). seeds extracted ethanol then first 50 mg/kg body weight /day 100 weight/day orally 15 days, following WHO guide lines (MB50). target organ, parameters viz. sperm motility, count fertility rate, Scanning Electron Microscopic (SEM) morphology spermatozoa ATPase activity were compared. Results: (BW)/day showed no significant change in epididymal compare control. Therefore dose changed BW/day days. organ weights (epididymis) animals not significantly (p>0.05). treatment brought about reduction rate when normal cycling female mated males (p<0.001). Decline caput cauda observed SEM photographs abnormal head bent mid-piece region. Conclusion: Decrease could attributed androgen dependent parameters. However, also reduced decrease motility their morphological abnormalities. Since manifested short period it evident that potential antifertility agent. As do cause weight, electrolyte balance.