Activation of Wnt Signaling in Cortical Neurons Enhances Glucose Utilization through Glycolysis

摘要: Abstract The Wnt signaling pathway is critical for a number of functions in the central nervous system, including regulation synaptic cleft structure and neuroprotection against injury. Deregulation has been associated with several brain pathologies, Alzheimer's disease. In recent years, it suggested that might act as integrator metabolic signals from peripheral organs to brain, which would represent new role cell metabolism. Energy metabolism normal neuronal function, mainly depends on glucose utilization. Brain energy important almost all neurological disorders, decrease capacity utilize linked. However, little known about relationship between cellular context. present study, we found acute treatment Wnt3a ligand induced large increase uptake, without changes expression or localization transporter type 3. addition, observed increased activation sensor Akt. Moreover, an activity hexokinase glycolytic rate, both processes were dependent Akt pathway. Furthermore, did not observe glucose-6-phosphate dehydrogenase pentose phosphate effect was independent transcription target genes effects Wnt3a. Together, our results suggest stimulates utilization cortical neurons through glycolysis satisfy high demand these cells.