Targeting the Tumor Microenvironment: From Understanding Pathways to Effective Clinical Trials

摘要: It is clear that tumor cells do not act alone but in close interaction with the extracellular matrix and stromal microenvironment (TME). As our understanding of cell-stroma interactions increased over last two decades, significant efforts have been made to develop agents interfere these interactions. Here, we discuss four different therapeutic strategies target TME, focusing on are at most advanced stage preclinical or clinical development. We end this review by outlining some lessons learned so far from development TME-targeting agents.