Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats.

摘要: Hepatocellular carcinoma is the most common primary cancer of liver in Asian countries. For more than a decade natural dietary agents including fruits, vegetables and spices have drawn great deal attention prevention diseases, preferably cancer. Ursolic acid triterpenoid widely found food, medicinal herbs, apple peel other products it has been extensively studied for its anticancer antioxidant properties. The purpose this study was to evaluate effect ursolic diethylnitrosamine (DEN) induced phenobarbital promoted hepatocarcinogenesis male Wistar rats. Antioxidant status assessed by alterations level lipid peroxides protein carbonyls. Damage plasma membrane levels tissue ATPases. Liver homogenized utilized estimation peroxides, carbonyls glycoproteins. Anticoagulated blood erythrocyte isolation. Oral administration UA 20 mg/kg body weight 6 weeks decreased at significance p<0.05. Activities ATPases returned normal after administration. Levels glycoproteins were also restored treatment. Histopathological observations recorded. findings from above suggest effectiveness reducing oxidative stress mediated changes Since be potent antioxidant, can suggested as an excellent chemopreventive agent overcoming diseases like which are free radicals.