Rapid modulation of the n-3 docosahexaenoic acid levels in the brain and retina of the newly hatched chick.

作者: G J Anderson , W E Connor , J D Corliss , D S Lin

DOI: 10.1016/S0022-2275(20)38358-9

关键词: IncubationFood scienceFatty acidBiochemistryFish oilEmbryoBiologyLinolenic acidYolkDocosahexaenoic acidLinseed oil

摘要: The newly hatched chick obtains its fatty acids almost completely from the lipids of egg yolk as these are transferred to developing embryo during 21-day period incubation. Since diet laying hen greatly influences acid composition lipids, and presumably also resulting chick, we tested how quickly what extent varying amount n-3 in would modulate level brain retina chick. White Leghorn hens were fed commercial or semi-purified diets supplemented with 10% fish oil, linseed soy safflower oil. Eggs, together brain, retina, serum chicks, then analyzed for composition. responded hen's most change occurring by 4 weeks. There was a linear relationship between linolenic content levels this serum. In chicks oil diet, total acids, including 22:6(n-3), elevated twofold sevenfold relative controls. led very low yolks only 25% control chicks.(ABSTRACT TRUNCATED AT 250 WORDS)

参考文章(42)
G.J. Marco, L.J. Machlin, E. Emery, R.S. Gordon, Dietary effects of fats upon fatty acid composition of the mitochondria. Archives of Biochemistry and Biophysics. ,vol. 94, pp. 115- 120 ,(1961) , 10.1016/0003-9861(61)90017-0
Janet Flier, Belur R. Lokesh, John E. Kinsella, Increased 5′ nucleotidase activity in plasma membranes from rat liver following ingestion of fish oil Nutrition Research. ,vol. 5, pp. 277- 283 ,(1985) , 10.1016/S0271-5317(85)80005-1
Alexander Leaf, Peter C. Weber, Cardiovascular effects of n-3 fatty acids The New England Journal of Medicine. ,vol. 318, pp. 549- 557 ,(1988) , 10.1056/NEJM198803033180905
Hans Mohrhauer †, Ralph T. Holman, ALTERATION OF THE FATTY ACID COMPOSITION OF BRAIN LIPIDS BY VARYING LEVELS OF DIETARY ESSENTIAL FATTY ACJDS Journal of Neurochemistry. ,vol. 10, pp. 523- 530 ,(1963) , 10.1111/J.1471-4159.1963.TB09855.X
Claudio Galli, Henryk I. Trzeciak, Rodolfo Paoletti, Effects of dietary fatty acids on the fatty acid composition of brain ethanolamine phosphoglyceride: Reciprocal replacement of n−6 and n−3 polyunsaturated fatty acids Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. ,vol. 248, pp. 449- 454 ,(1971) , 10.1016/0005-2760(71)90233-5
D. Balnave, Essential fatty Acids in Poultry Nutrition Worlds Poultry Science Journal. ,vol. 26, pp. 442- 460 ,(1970) , 10.1079/WPS19700006
M Neuringer, W E Connor, C Van Petten, L Barstad, Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. Journal of Clinical Investigation. ,vol. 73, pp. 272- 276 ,(1984) , 10.1172/JCI111202
M Neuringer, G J Anderson, W E Connor, The Essentiality of N-3 Fatty Acids for the Development and Function of the Retina and Brain Annual Review of Nutrition. ,vol. 8, pp. 517- 541 ,(1988) , 10.1146/ANNUREV.NU.08.070188.002505