Documentation of Intraretinal Retinal Pigment Epithelium Migration via High-Speed Ultrahigh-Resolution Optical Coherence Tomography

摘要: Purpose To describe the features of intraretinal retinal pigment epithelium (RPE) migration documented on a prototype spectral-domain, high-speed, ultrahigh-resolution optical coherence tomography (OCT) device in group patients with early to intermediate dry age-related macular degeneration (AMD) and correlate RPE OCT clumping fundus photographs. Design Retrospective, noncomparative, noninterventional case series. Participants Fifty-five eyes 44 seen at New England Eye Center between December 2007 June 2008 AMD. Methods Three-dimensional scan sets from all were analyzed for presence migration, defined as small discreet hyperreflective highly backscattering lesions within neurosensory retina. Fundus photographs also determine clumping, black, often spiculated, areas macula. The en face images correlated demonstrate correspondence photography. Main Outcome Measures Drusen, AMD, clumping. Results On scans, 54.5% (61.4% patients) demonstrated migration. Of photographs, 56.4% All had corresponding migrated most frequently into outer nuclear layer (66.7% eyes) less more anterior layers. Intraretinal mainly occurred above drusen (73.3% eyes). Conclusions appearance is common occurrence occurring eyes, or 61.4% patients. area always Conversely, but 1 eye photography OCT. high incidence observed suggests that may play physical catalytic roles facilitating AMD Financial Disclosure(s) Proprietary commercial disclosure be found after references.