Expression of the p53 protein in malignant melanomas as a prognostic indicator

摘要: It is currently widely accepted that the tumour suppressor gene p53 critically involved in proliferation and differentiation of cells including melanoma cells. In present study, we examined 60 cases primary to compare expression protein with conventional prognostic markers for such as clinical histological parameters. No correlation was found between factors except presence a metastatic node development stage II. However, significantly associated thickness over 1.5 mm, levels IV V invasion, ulceration, high mitotic rate 5-year survival rate. Although many questions still remain be answered, our results those others various other malignant tumours, implicate transformation pigment Indeed, it could new marker an unfavourable prognosis melanoma, even though mutation this highly lethal has yet established.