The role of host cell Rab GTPases in influenza A virus infections.
作者： Shengjun Wang , Li Shen , Jing Wu , Jiaqi Gu , Lingxiang Mao
关键词: Biology 、 Critical factors 、 Viral pathogenesis 、 Virology 、 GTPase 、 SUPERFAMILY 、 Small GTPase 、 Viral entry 、 Influenza A virus 、 Rab
摘要: Influenza A virus (IAV) is a crucial cause of respiratory infections in humans worldwide. Therefore, studies should clarify adaptation mechanisms of IAV and critical factors of the viral pathogenesis in human hosts. GTPases of the Rab family are the largest branch of the Ras-like small GTPase superfamily, and they regulate almost every step during vesicle-mediated trafficking. Evidence has shown that Rab proteins participate in the lifecycle of IAV. In this mini-review, we outline the regulatory mechanisms of different Rab proteins in the …
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