Analyses of microsatellite instability and the transforming growth factor‐β receptor type II gene mutation in sporadic breast cancer and their correlation with clinicopathological features
作者： Shuji Tomita , Shigeru Deguchi , Takao Miyaguni , Yoshihiro Muto , Tohru Tamamoto
关键词: Single-strand conformation polymorphism 、 Tumor progression 、 Biology 、 Cancer research 、 Gene 、 Gene mutation 、 Mammary gland 、 Breast cancer 、 Microsatellite instability 、 Mutation
摘要: To determine the incidence of microsatellite instability (MSI) and its relationship with both clinicopathologic parameters patient survival, 101 cases breast cancer were investigated. In addition, transforming growth factor‐β (TGF‐β) receptor type II (RII) gene mutation was also examined to clarify relation MSI in development. RII screened by single strand conformation polymorphism (SSCP). The mutations confirmed a direct sequence. An association between status clinicopathological features assess potential as prognostic indicator sporadic cases. detected 12 (11.9%) positive showed relatively more advanced disease than negative cases, exhibited poorer prognoses. No observed any Our data suggest that may thus be useful for prognosis However, seems an infrequent target organ development through mutations. As result, tumor progression this pathway appears related specificity. For cancers, other genes therefore still need identified.
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