Increased choline levels coincide with enhanced proliferative activity of human neuroepithelial brain tumors

摘要: Proton MR spectroscopy ((1)H MRS)-visible total choline-containing compounds (tCho-compounds) are derivatives of membrane phospholipids and, in part, may act as a long-term second-messenger system for cellular proliferation. Experimental evidence suggests increasing concentrations tCho-compounds during The present study was conducted order to test the hypothesis that vivo measurements tCho-concentrations using (1)H MRS allow assessment proliferative activity neuroepithelial brain tumors presurgically. Single-voxel (PRESS, TR 1500 ms, TE 135 ms) performed 101 patients with prior surgery and 19 healthy volunteers. Histological diagnoses were confirmed postsurgically according WHO classification. Measured tCho-compound signal intensities corrected coil loading, numbers acquisitions voxel size, tCho calculated institutional arbitrary units. They matched mean immunohistochemical marker cell proliferation, Ki-67 (MIB.1) labeling index, correlation analysis Spearman. Compared low-grade (i.e. grade I/II) normal white matter, high-grade III/IV) revealed significantly (p < 0.05) elevated indices paralleled by increasingly tCho-concentrations. In contrast tumor did not differ from physiological values. A highly significant positive 0.0001, r(2) = 0.81) found between tCho-concentration index. It concluded determination could provide novel noninvasive tumors, pointing at useful method differentiating proliferating non-proliferating tissues. Hence, potential indications clinical application grading presurgically, early detection anaplastic transformation, monitoring treatment.