CNTF regulation of astrogliosis and the activation of microglia in the developing rat central nervous system

摘要: In response to physical or chemical brain injury, the mammalian central nervous system (CNS) often reacts by evoking astrogliosis. The most prominent feature describing this state is an upregulation of glial fibrillary acidic protein (GFAP). agent(s) responsible for inducing astrogliosis remains unclear; however, recent observations have shown cytokines may play a pivotal role. During CNS trauma, macrophages and lymphocytes infiltrate where they are thought synthesize secrete cytokines; moreover, activated microglia reactive astrocytes known be capable cytokine production. We first report that intracerebral injection pleiotropic cytokine, ciliary neurotrophic factor (CNTF), increases appearance in neonatal rat. This CNTF was comparable observed animals receiving well pro-inflammatory tumor necrosis factor-alpha (TNF-alpha). Only moderate increase proliferative index cytokine-injected animals; therefore, we conclude GFAP largely upregulated pre-existing negative cell population. Interestingly, coinjections TNF-alpha appeared act synergistically. Coinjected displayed wave hypertrophied reaching far into contralateral hemisphere. No spreading observed. article clearly provides interesting information regarding regulatory mechanisms govern discusses probable relationship microglia.