Dissecting the Heterogeneity in T-Cell Mediated Inflammation in IBD.

摘要: Infiltration of the lamina propria by inflammatory CD4+ T-cell populations is a key characteristic chronic intestinal inflammation. Memory-phenotype frequencies are increased in inflamed tissue IBD patients compared to healthy controls and associated with disease flares more complicated course. Therefore, tightly controlled balance between regulatory crucial prevent uncontrolled responses subsequent damage. While at steady state, T-cells display mainly phenotype, Th1, Th2, Th9, Th17, Th17.1 responses, reduced Treg Tr1 have all been suggested play role pathophysiology. However, it highly unlikely that these altered each individual patient. With rapidly expanding plethora therapeutic options inhibit stimulate need emerging for robust set immunological assays predict monitor success an level. Consequently, differentiate dominant T helper relate course therapy response. In this review, we provide overview how arise, discuss main phenotypes review they implicated IBD.