The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.

作者: Fadil M. Hannan , Enikö Kallay , Wenhan Chang , Maria Luisa Brandi , Rajesh V. Thakker

DOI: 10.1038/S41574-018-0115-0

关键词: EndocrinologySecondary hyperparathyroidismHormoneMedicineInternal medicineNutrient sensingEnteroendocrine cellReceptorCalcium-sensing receptorHomeostasisParathyroid hormone secretion

摘要: The Ca 2+ -sensing receptor (CaSR) is a dimeric family CG protein-coupled receptor that is expressed in calcitropic tissues such as the parathyroid glands and the kidneys and signals …

参考文章(258)
E. F. Nemeth, W. G. Goodman, Calcimimetic and Calcilytic Drugs: Feats, Flops, and Futures Calcified Tissue International. ,vol. 98, pp. 341- 358 ,(2016) , 10.1007/S00223-015-0052-Z
Eleanor Spreckley, The L-Cell in Nutritional Sensing and the Regulation of Appetite Frontiers in Nutrition. ,vol. 2, pp. 23- 23 ,(2015) , 10.3389/FNUT.2015.00023
Aldebaran M. Hofer, Edward M. Brown, Extracellular calcium sensing and signalling. Nature Reviews Molecular Cell Biology. ,vol. 4, pp. 530- 538 ,(2003) , 10.1038/NRM1154
Sabrina Corbetta, Giovanna Mantovani, Andrea Lania, Stefano Borgato, Leonardo Vicentini, Beretta, Giovanni Faglia, Anna Maria Di Blasio, Anna Spada, Calcium‐sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia Clinical Endocrinology. ,vol. 52, pp. 339- 348 ,(2000) , 10.1046/J.1365-2265.2000.00933.X
Brenda A. Finney, Pierre M. Del Moral, William J. Wilkinson, Sebastien Cayzac, Martin Cole, David Warburton, Paul J. Kemp, Daniela Riccardi, Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR. The Journal of Physiology. ,vol. 586, pp. 6007- 6019 ,(2008) , 10.1113/JPHYSIOL.2008.161687
Fadil M. Hannan, Gerard V. Walls, Valerie N. Babinsky, M. Andrew Nesbit, Enikö Kallay, Tertius A. Hough, William D. Fraser, Roger D. Cox, Jianxin Hu, Allen M. Spiegel, Rajesh V. Thakker, The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1) Endocrinology. ,vol. 156, pp. 3114- 3121 ,(2015) , 10.1210/EN.2015-1269
Irfete S. Fetahu, Samawansha Tennakoon, Kate E. Lines, Charlotte Gröschel, Abhishek Aggarwal, Ildiko Mesteri, Sabina Baumgartner-Parzer, Robert M. Mader, Rajesh V. Thakker, Enikő Kállay, miR‐135b‐ and miR‐146b‐dependent silencing of calcium‐sensing receptor expression in colorectal tumors International Journal of Cancer. ,vol. 138, pp. 137- 145 ,(2016) , 10.1002/IJC.29681
Floriana Elsholz, Christian Harteneck, Walter Muller, Kristina Friedland, Calcium - a central regulator of keratinocyte differentiation in health and disease European Journal of Dermatology. ,vol. 24, pp. 650- 661 ,(2014) , 10.1684/EJD.2014.2452
Eric G. Delmar, Maxine Gowen, Rebecca L. Conklin, John Fox, William L. Heaton, Michael A. Miller, Pradip K. Bhatnagar, Lyssa D. Lambert, Edward F. Nemeth, John G. Gleason, Calcilytic Compounds: Potent and Selective Ca2+Receptor Antagonists That Stimulate Secretion of Parathyroid Hormone Journal of Pharmacology and Experimental Therapeutics. ,vol. 299, pp. 323- 331 ,(2001)