Phosphorylation of CBP by IKKα Promotes Cell Growth by Switching the Binding Preference of CBP from p53 to NF-κB
作者： Wei-Chien Huang , Tsai-Kai Ju , Mien-Chie Hung , Ching-Chow Chen
DOI: 10.1016/J.MOLCEL.2007.02.019
关键词: Cell cycle 、 Cell growth 、 Crosstalk (biology) 、 Biology 、 Cancer research 、 Phosphorylation 、 CREB-binding protein 、 Transcription factor 、 NFKB1 、 Signal transduction
摘要: … is regulated, we unexpectedly found that IKKα regulates the interaction of CBP with NF-κB and … Our data showed that not only phosphorylation of p65 at Ser276 but also IKKα-mediated …
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