Optimising plasticity: environmental and training associated factors in transplant-mediated brain repair.

摘要: With progressively ageing populations, degeneration of nerve cells the brain, due to accident or disease, represents one major problems for health and welfare in developed world. The molecular environment adult brain promotes stability limiting its ability regenerate repair itself following injury. Cell transplantation aims nervous system by introducing new that can replace function compromised lost cells. Alternatives primary embryonic tissue are actively being sought but this is at present only source has been shown reliably survive grafting into spinal cord, connect with host system, influence behaviour. Based on animal studies, several clinical trials have now grafts partially alleviate symptoms Parkinson's related strategies under evaluation Huntington's cord injury, stroke other CNS disorders. most plastic period offering a window opportunity therapeutic intervention. Enriched environment, behavioural experience each separately neuronal plasticity recovery after damage, extent which these factors interact unknown. To improve outcome must make use endogenous potential both graft optimise external circumstances associated graft-mediated recovery. Our understanding mechanisms subsequent damage needs be what we know about enhancing intrinsic processes order neurobiological surgical level. proof principle beginning emerge from trials, rich area innovative research profound application, even broader than specific context transplantation, opening investigation.