作者: Hongmei Zhang , Kimberly Yolton , Glenys M. Webster , Xiaoyun Ye , Antonia M. Calafat
DOI: 10.1016/J.ENVINT.2017.11.031
关键词: Letter word 、 Reading skills 、 Medicine 、 Young adult 、 Word reading 、 Background exposure 、 Demography 、 Early childhood 、 Pregnancy 、 Gestation
摘要: Abstract Background Exposure to perfluoroalkyl substances (PFASs) may impact children's neurodevelopment. Objective To examine the association of prenatal and early childhood serum PFAS concentrations with reading skills at ages 5 8 years. Methods We used data from 167 mother-child pairs recruited during pregnancy (2003–2006) in Cincinnati, OH, quantified 16 ± 3 weeks gestation sera 3 assessed using Woodcock-Johnson Tests Achievement III age 5 years Wide Range Test-4 general linear regression quantify covariate-adjusted associations between natural log-transformed skills, multiple informant model identify potential windows susceptibility. Results Median PFASs were PFOS > PFOA > PFHxS > PFNA prenatal, 3-year, 8-year children. The identified positive PFOA, PFOS PFNA scores 8 years, but no any PFHxS concentration skills. showed: a) Prenatal PFOA was positively associated higher Reading Composite (β: 4.0, 95% CI: 0.6, 7.4 per a log unit increase exposure) Sentence Comprehension 4.2, 0.5, 8.0) 8 years; b) 3-year Brief 7.3, 0.9, 13.8), Letter Word Identification 6.6, 1.1, 12.0), Passage 5.9, 1.5, 10.2) 5 years; c) 5.8, 0.8, 10.7) abilities 5 years, not 5 years. But concentrations, exposure windows, Conclusion better found