Prenatal and childhood perfluoroalkyl substances exposures and children's reading skills at ages 5 and 8 years

作者: Hongmei Zhang , Kimberly Yolton , Glenys M. Webster , Xiaoyun Ye , Antonia M. Calafat

DOI: 10.1016/J.ENVINT.2017.11.031

关键词: Letter wordReading skillsMedicineYoung adultWord readingBackground exposureDemographyEarly childhoodPregnancyGestation

摘要: Abstract Background Exposure to perfluoroalkyl substances (PFASs) may impact children's neurodevelopment. Objective To examine the association of prenatal and early childhood serum PFAS concentrations with reading skills at ages 5 8 years. Methods We used data from 167 mother-child pairs recruited during pregnancy (2003–2006) in Cincinnati, OH, quantified 16 ± 3 weeks gestation sera 3 assessed using Woodcock-Johnson Tests Achievement III age 5 years Wide Range Test-4 general linear regression quantify covariate-adjusted associations between natural log-transformed skills, multiple informant model identify potential windows susceptibility. Results Median PFASs were PFOS > PFOA > PFHxS > PFNA prenatal, 3-year, 8-year children. The identified positive PFOA, PFOS PFNA scores 8 years, but no any PFHxS concentration skills. showed: a) Prenatal PFOA was positively associated higher Reading Composite (β: 4.0, 95% CI: 0.6, 7.4 per a log unit increase exposure) Sentence Comprehension 4.2, 0.5, 8.0) 8 years; b) 3-year Brief 7.3, 0.9, 13.8), Letter Word Identification 6.6, 1.1, 12.0), Passage 5.9, 1.5, 10.2) 5 years; c) 5.8, 0.8, 10.7) abilities 5 years, not 5 years. But concentrations, exposure windows, Conclusion better found

参考文章(49)
Nancy Mather, Barbara J. Wendling, Richard W. Woodcock, Essentials of WJ III Tests of Achievement Assessment ,(2001)
Stefan Hallgren, Anders Fredriksson, Henrik Viberg, More signs of neurotoxicity of surfactants and flame retardants - Neonatal PFOS and PBDE 99 cause transcriptional alterations in cholinergic genes in the mouse CNS. Environmental Toxicology and Pharmacology. ,vol. 40, pp. 409- 416 ,(2015) , 10.1016/J.ETAP.2015.06.014
Ron Dumont, John O. Willis, Kathleen Veizel, Jamie Zibulsky, Wechsler Abbreviated Scale of Intelligence Encyclopedia of Special Education. ,(2014) , 10.1002/9781118660584.ESE2519
Yan Wang, Walter J. Rogan, Hsin-Yi Chen, Pau-Chung Chen, Pen-Hua Su, Hsiao-Yen Chen, Shu-Li Wang, Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study. International Journal of Hygiene and Environmental Health. ,vol. 218, pp. 639- 644 ,(2015) , 10.1016/J.IJHEH.2015.07.002
Cheryl R. Stein, David A. Savitz, David C. Bellinger, Perfluorooctanoate exposure in a highly exposed community and parent and teacher reports of behaviour in 6-12-year-old children. Paediatric and Perinatal Epidemiology. ,vol. 28, pp. 146- 156 ,(2014) , 10.1111/PPE.12097
Matthias Kotthoff, Josef Müller, Heinrich Jürling, Martin Schlummer, Dominik Fiedler, Perfluoroalkyl and polyfluoroalkyl substances in consumer products Environmental Science and Pollution Research. ,vol. 22, pp. 14546- 14559 ,(2015) , 10.1007/S11356-015-4202-7
Hermann Fromme, Sheryl A. Tittlemier, Wolfgang Völkel, Michael Wilhelm, Dorothee Twardella, Perfluorinated compounds--exposure assessment for the general population in Western countries. International Journal of Hygiene and Environmental Health. ,vol. 212, pp. 239- 270 ,(2009) , 10.1016/J.IJHEH.2008.04.007
Angela D. Friederici, The Brain Basis of Language Processing: From Structure to Function Physiological Reviews. ,vol. 91, pp. 1357- 1392 ,(2011) , 10.1152/PHYSREV.00006.2011
Kay B. Stevens, J. Randall Price, Adult reading assessment: are we doing the best with what we have? Applied Neuropsychology. ,vol. 6, pp. 68- 78 ,(1999) , 10.1207/S15324826AN0602_2
Kayoko Kato, Brian J. Basden, Larry L. Needham, Antonia M. Calafat, Improved selectivity for the analysis of maternal serum and cord serum for polyfluoroalkyl chemicals. Journal of Chromatography A. ,vol. 1218, pp. 2133- 2137 ,(2011) , 10.1016/J.CHROMA.2010.10.051