Serum 25-hydroxyvitamin D and glycated haemoglobin levels in women with gestational diabetes mellitus.

摘要: Objective: To test the hypothesis that lower 25-hydroxyvitamin D (25[OH]D) levels in late pregnancy are associated with poorer glucose control gestational diabetes mellitus (GDM). Design and setting: Retrospective cross-sectional study, a GDM clinic at tertiary referral centre. Patients: Women attending Westmead Hospital from 1 February 2007 to 2008, excluding those prepregnancy intolerance. Main outcome measures: Levels of glycated haemoglobin (HbA1c) 25(OH)D measured during third trimester; maternal age, ethnicity, body mass index (BMI) occupational status; results oral tolerance testing (OGTT). Results: 147 women mean age 35 ± 2 weeks were included, whom 41% had insufficient or deficient ( 50 nmol/L). Ethnicity, status season significantly influenced (P < 0.01 for all) but BMI did not. inversely fasting 2-hour blood OGTT (Spearman r = − 0.16; P 0.05 both) log[HbA1c] 0.32; 0.001). insulin doses also HbA1c levels. Multivariable analysis identified as independent predictors Conclusions: Lower independently glycaemic control. Future randomised trials needed determine whether vitamin plays role GDM. Regardless, insufficiency has adverse effects including neonatal hypocalcaemia rickets. The prevalence inadequate our study is unacceptably high. We propose routine all pregnant screening earlier,