Acceptability of hypothetical dengue vaccines among travelers.

摘要: Background Dengue viruses have spread widely in recent decades and cause tens of millions infections mostly tropical subtropical areas. Vaccine candidates are being studied aggressively may be ready for licensure soon. Methods We surveyed patients with past or upcoming travel to dengue-endemic countries assess rates determinants acceptance four hypothetical dengue vaccines variable efficacy adverse event (AE) profiles. Acceptance ratios were calculated varied AE risk. Results Acceptance the ranged from 54% vaccine lower serious risk 95% higher minor risk. Given equal efficacy, better accepted than those risk; given equivalent risk, efficacy. History Japanese encephalitis vaccination was associated one vaccines. US-born travelers more likely non-US born accept a 75% AEs (p = 0.003). Compared North American-born travelers, Asian- African-born less both efficacy. Conclusions Most would safe efficacious if available. Travelers valued fewer potential over increased