Dengue Virus Seroconversion in Travelers to Dengue-Endemic Areas

摘要: We conducted a prospective study to measure dengue virus (DENV) antibody seroconversion in travelers dengue-endemic areas. Travelers seen the Boston Area Travel Medicine Network planning visit countries for ≥ 2 weeks were enrolled from 2009 2010. Pre- and post-travel blood samples questionnaires collected. Post-travel sera tested anti-DENV IgG by indirect enzyme-linked immunosorbent assay (ELISA) IgM capture ELISA. Participants with positive or pre-travel IgM; they excluded calculation if either positive. Paired collected 62% (589/955) of travelers. Most participants 19-64 years age, female, white. The most common purposes travel tourism visiting friends relatives; trips Asia Africa. Median length was 21 days. DENV ELISA 2.9-6.8%; lower range percent potential false-positive due receipt yellow fever Japanese encephalitis vaccines at enrollment; upper proven IgM. Eighteen those reported dengue-like symptoms. Seroconversion documented Africa as well regions known be highly endemic (India, Brazil, southeast Asia). Given widespread risk dengue, medicine counseling should include information on areas advice preventing insect bites seeking prompt medical attention febrile illness.