Prediction of human microRNA targets.
作者： Bino John , Chris Sander , Debora S. Marks
DOI: 10.1385/1-59745-123-1:101
关键词: Human genome 、 Gene expression 、 microRNA 、 Regulation of gene expression 、 Biology 、 Gene 、 Three prime untranslated region 、 Gene silencing 、 Computational biology 、 RNA
摘要: MicroRNAs (miRNAs) are small, nonprotein-coding RNAs that regulate gene expression. Although hundreds of human miRNA genes have been discovered, the functions most these unknown. Computational predictions indicate miRNAs, which account for at least 1% protein-coding genes, protein production thousands or possibly all genes. We discuss mammalian miRNAs and experimental computational methods used to detect predict target Anticipating their impact on genome-wide discovery targets, we describe various tools web-based resources available targets.
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