Group choreography: mechanisms orchestrating the collective movement of border cells

摘要: Cell movements are essential for animal development and homeostasis but also contribute to disease. Moving cells typically extend protrusions towards a chemoattractant, adhere the substrate, contract detach at rear. It is less clear how that migrate in interconnected groups vivo coordinate their behaviour navigate through natural environments. The border of Drosophila melanogaster ovary have emerged as an excellent model study collective cell movement, aided by innovative genetic, live imaging, photomanipulation techniques. Here we provide overview molecular choreography its more general implications.