Epidermal Growth Factor Receptor as a Novel Therapeutic Target in Anaplastic Thyroid Carcinomas
作者： C ENSINGER , G SPIZZO , P MOSER , I TSCHOERNER , R PROMMEGGER
关键词: Carcinoma 、 Epidermal growth factor receptor 、 Targeted Molecular Therapy 、 Thyroid carcinoma 、 Pathology 、 Immunohistochemistry 、 Cancer research 、 Immunotherapy 、 Biology 、 Receptor 、 Poorly Differentiated Thyroid Carcinoma
摘要: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies, with a median survival up to 6 months. Such bad prognosis under present treatment procedures suggests need for novel approaches in management this disease. Since some epidermal growth factor receptor (EGFR) inhibitors are now clinical trials and few data available concerning EGFR expression anaplastic carcinomas, we tried estimate possible overexpression larger tumor series. Twenty-five ATCs, including 3 ATCs poorly differentiated (PDTC) parts, were immunohistochemically investigated mouse monoclonal antibody directed against (EGFR pharmDX kit). The tumors revealed primarily distinct membranous staining pattern, several cells an additional cytoplasmic reactivity could be observed. carcinomas presented 5 25 (20%) without reaction, 10 (40%) reactivity, receptor. All PDTC parts (100%) showed overexpression. Cytoplasmic was observed 56% all ATCs. A significant correlation calculated (P = 0.036). Concerning overexpression, significantly different from 0.023). For first time, ATC series, demonstrating that common finding ATC. at least one-third seems promising agent targeted molecular therapy these extraordinarily tumors.
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