Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections.

摘要: Virus-infected cells secrete a broad range of interferons (IFN) which confer resistance to yet uninfected by triggering the synthesis antiviral factors. The relative contribution various IFN subtypes innate immunity against virus infections remains elusive. IFN-alpha, IFN-beta and other type I molecules signal through common universally expressed cell surface receptor, whereas III (IFN-lambda) uses distinct type-specific receptor complex for signaling. Using mice lacking functional receptors IFN, or both, we found that IFN-lambda plays an important role in defense several human pathogens infect respiratory tract such as influenza A virus, B syncytial metapneumovirus SARS coronavirus. These viruses were more pathogenic replicated higher titers lung both than with single defects. By contrast, Lassa fever infects via but primarily replicates liver, was not influenced defect. Careful analysis revealed expression complexes intestinal is restricted epithelial few undefined types. Interestingly, coronavirus present feces from infected receptors, supporting view contributes control viral gastrointestinal tract.