The glyoxylate cycle and alternative carbon metabolism as metabolic adaptation strategies of Candida glabrata : perspectives from Candida albicans and Saccharomyces cerevisiae

摘要: Carbon utilization and metabolism are fundamental to every living organism for cellular growth. For intracellular human fungal pathogens such as Candida glabrata, an effective metabolic adaptation strategy is often required survival pathogenesis. As one of the host defence strategies combat invading pathogens, phagocytes macrophages constantly impose restrictions on pathogens’ access their preferred carbon source, glucose. Surprisingly, it has been reported that engulfed C. glabrata able survive in this harsh microenvironment, further suggesting alternative a potential opportunistic pathogen persist host. In review, we discuss pathogenesis glabrata. glyoxylate cycle important pathway sources, also highlight key enzymes its necessity Finally, explore transcriptional regulatory network cycle. Considering evidence from albicans Saccharomyces cerevisiae, review summarizes current knowledge