Polymorphism rs1761667 in the CD36 Gene Is Associated to Changes in Fatty Acid Metabolism and Circulating Endocannabinoid Levels Distinctively in Normal Weight and Obese Subjects.
作者： Melania Melis , Gianfranca Carta , Stefano Pintus , Paolo Pintus , Carla A. Piras
关键词: Endocannabinoid system 、 Internal medicine 、 Endocrinology 、 Fatty acid metabolism 、 Scavenger receptor 、 CD36 、 Metabolism 、 Dyslipidemia 、 Chemistry 、 Lipogenesis 、 Fatty acid
摘要: The multifunctional CD36 scavenger receptor facilitates fatty acid (FA) uptake and oxidation it has been involved in the pathophysiology related to dysfunctional FA metabolism. common variant gene, rs1761667 (A/G), whose allele A is characterized by a reduced protein expression, associated with taste sensitivity preference for fat. We therefore aimed at evaluating whether polymorphism may influence metabolism endocannabinoid biosynthesis normal weight (NW) obese (OB) subjects. Red blood cell (RBC) composition, plasma levels were determined. In NW subjects AA genotype was found marked reduction of RBC saturated acids palmitic/linoleic ratio (PA/LA), considered as de novo lipogenesis (DNL) biomarkers. Remarkably, DNL biomarkers corresponded an increase omega-6 index, indirect marker impact on dietary acids, higher waist/hip ratio. presence G instead increased trend subjects, even though exhibited decreased BMI respect those genotype. These data indicate that polymorphism, rs1761667, leads distinct metabolic pattern OB Therefore, their determination be crucial developing personalized therapeutic strategies ameliorating dyslipidemia other disorders.
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