Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development
作者： Nadege Vernet , Shantha K. Mahadevaiah , Fanny Decarpentrie , Guy Longepied , Dirk G. de Rooij
DOI: 10.1371/JOURNAL.PONE.0145398
关键词: Meiosis 、 X chromosome 、 Zinc finger 、 Biology 、 Sperm 、 Gene 、 Genetics 、 Promoter 、 Fusion gene 、 Y chromosome
摘要: A previous study indicated that genetic information encoded on the mouse Y chromosome short arm (Yp) is required for efficient completion of second meiotic division (that generates haploid round spermatids), restructuring sperm head, and development tail. Using models lacking a but with varying Yp gene complements provided by chromosomal derivatives or transgenes, we recently identified Y-encoded zinc finger transcription factors Zfy1 Zfy2 as genes promoting division. same here show (but not Zfy1) contributes to head The preferential involvement consistent presence an additional strong spermatid-specific promotor has been acquired this gene. This further supported fact promotion morphogenesis also seen in one two markedly deficient which deletion created Zfy2/1 fusion driven promotor, encodes protein almost identical Zfy1. Our results point there being role head.
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