Scavenger Receptor-A–Targeted Leukocyte Depletion Inhibits Peritoneal Ovarian Tumor Progression

摘要: Immunosuppressive leukocytes are emerging as a critical factor in facilitating tumor progression. These converted by the microenvironment to become tolerogenic, facilitate metastasis, and aid neovascularization. The predominant variety of suppressive found human murine ovarian cancer called vascular (VLC), due sharing functions cell surface markers both dendritic cells endothelial cells. Using ID8 model cancer, aim this study was test efficacy VLC elimination an therapy. We show that carrageenan-mediated depletion peritoneal tumor-associated inhibits then identified scavenger receptor-A (SR-A) receptor is robustly specifically expressed within ascites upon VLCs. Administration anti-SR-A immunotoxin mice challenged with tumors eliminated VLCs and, importantly, substantially inhibited burden accumulation. Moreover, toxin required targeting SR-A because received untargeted did not exhibit inhibition conclude constitutes novel specific target for efficacious immunotherapeutic treatment cancer.