Comorbid ADHD is associated with altered patterns of neuronal activation in adolescents with bipolar disorder performing a simple attention task.

摘要: Objective:  Bipolar disorder is increasingly recognized as a significant source of psychiatric morbidity in children and adolescents. Younger bipolar patients symptomatically differ from adults, frequently present with comorbid disorders, particularly attention-deficit hyperactivity (ADHD). The neurophysiological relationship between these two however, remains unclear. In this study we utilized functional magnetic resonance imaging (fMRI) to compare activation patterns during performance simple attention task adolescents without ADHD. Methods:  Eleven ADHD 15 comorbidity were recruited participate fMRI scans. A single-digit continuous alternated control block-design paradigm. between-group comparisons made using voxel-by-voxel analysis. Follow-up correlations activation. Results:  Group did not significantly percentage correct (p = 0.36) or discriminability (p = 0.11). was associated less the ventrolateral prefrontal cortex (Brodmann 10) anterior cingulate, greater posterior parietal middle temporal gyrus. Comorbid substantial differences correlation activation. Conclusions:  Our findings suggest that alternative pathways task. pattern suggests demonstrate decreased regions, compared ADHD, preferentially recruit portions cortex.