Diterpenoids of the Cassane Type from Caesalpinia decapetala
作者： Yuben Qiao , Qianqian Xu , Zhengxi Hu , Xiao-Nian Li , Ming Xiang
DOI: 10.1021/ACS.JNATPROD.6B00910
关键词: Caesalpinia 、 Ic50 values 、 Chemistry 、 Circular dichroism 、 Pancreatic cancer cell 、 Stereochemistry 、 Chemical constituents
摘要: Eighteen compounds, including eight new cassane-type furanoditerpenoids, 3β-hydroxyphanginin H (1), 3β-acetoxyphanginin (2), 7β-acetoxyphanginin (3), 7β-hydroxyphanginin (4), 4-epi-3β-hydroxycaesalpinilinn (5), 4-epi-3β-acetoxycaesalpinilinn (6), 20-acetoxytaepeenin D (7), and tomocin E (8), along with 10 known compounds (9–18) were isolated from the roots of Caesalpinia decapetala. Compounds 1–13 C. decapetala for first time. The their absolute configurations determined by extensive spectroscopic analysis, single-crystal X-ray diffraction, electronic circular dichroism calculations. 1, 4, 5, 7, 11 exhibited inhibitory activities against SW1990 human pancreatic cancer cell line IC50 values ranging 2.9 to 8.9 μM.
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