Effects of Phthalate Esters on Dendritic Cell Subsets and Interleukin-4 Production in Fluorescein Isothiocyanate-Induced Contact Hypersensitivity
作者： Takashi Maruyama , Takahiro Shiba , Hiromi Iizuka , Tomoko Matsuda , Kohta Kurohane
DOI: 10.1111/J.1348-0421.2007.TB03914.X
关键词: Molecular biology 、 Adjuvant 、 Immunology 、 Lymph 、 Cell migration 、 Dendritic cell 、 Fluorescein isothiocyanate 、 Biology 、 Phthalate 、 Interleukin 4 、 Integrin alpha M 、 Microbiology 、 Virology
摘要: Phthalate esters with short alkyl chains, such as di-ethyl (DEP), di-n-propyl (DPP), and di-butyl phthalate (DBP), have adjuvant effects on an FITC-induced contact hypersensitivity mouse model. The of DPP DBP are associated enhanced trafficking FITC-presenting CD11b � dendritic cells (DC). DEP has relatively weak activity to FITC-positive cell migration. Here we demon- strated that also increased the number CD8alpha DC in draining lymph nodes. We found production interleukin-4 nodes after FITC sensitiza- tion DEP, DPP, or DBP, suggesting additional mechanism esters.
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