Prenatal Stress and Stress Coping Style Interact to Predict Metabolic Risk in Male Rats
作者： Gretha J. Boersma , Alexander A. Moghadam , Zachary A. Cordner , Kellie L. Tamashiro
DOI: 10.1210/EN.2013-1874
关键词: Insulin 、 Medicine 、 Offspring 、 Hormone 、 Prenatal care 、 Type 2 diabetes 、 Endocrinology 、 Insulin resistance 、 Glucose tolerance test 、 Prenatal stress 、 Internal medicine
摘要: Both prenatal stress (PNS) exposure and a passive stress-coping style have been identified as risk factors for insulin resistance in rats. In the current study, we test hypothesis that PNS may interact predicting susceptibility metabolic disease. To this hypothesis, adult male control offspring were behaviorally characterized using defensive burying to either or proactive style. adulthood, all rats fed standard chow high-fat diet 3 weeks. After weeks of exposure, glucose levels assessed during an oral tolerance test. Under conditions, display elevated responses test, indicative intolerance. Interestingly, these effects far more pronounced by Additionally, passively coping also gained weight on than other tested. This observation suggests stressful environment combination with strategy prime individual be sensitive diet-induced obesity type 2 diabetes.
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