OPEN COMPARISON OF INTRAMUSCULAR CHLOROQUINE AND QUININE IN CHILDREN WITH SEVERE CHLOROQUINE-SENSITIVE FALCIPARUM MALARIA
作者： N.J White , D Waller , D Kwiatkowski , S Krishna , C Craddock
DOI: 10.1016/S0140-6736(89)91918-1
关键词: Malaria 、 Pharmacology 、 Protozoal disease 、 Medicine 、 Immunology 、 Chloroquine 、 Plasmodium falciparum 、 Random allocation 、 Quinine
摘要: An open paired randomised comparison of intramuscular chloroquine (3.5 mg base/kg every 6 h) and quinine (20 salt/kg followed by 10 mg/kg 12 was carried out in 50 Gambian children with severe falciparum malaria. 8 died, from the quinine-treated 2 chloroquine-treated group. Chloroquine reduced parasitaemia significantly more rapidly than did quinine, but other measures therapeutic response were similar two groups. Quinine injections painful. These findings do not support proposition that is intrinsically superior to treatment drug-sensitive
tropmedres.ac参考文章(19)
Nicholas J. White, David A. Warrell, Sornchai Looareesuwan, Mary J. Warrell, Pornthep Chanthavanich, Danai Bunnag, Tranakchit Harinasuta, Quinine Loading Dose in Cerebral Malaria * The American Journal of Tropical Medicine and Hygiene. ,vol. 32, pp. 1- 5 ,(1983) , 10.4269/AJTMH.1983.32.1
Clinical Features and Prognostic Indicators in Paediatric Cerebral Malaria: A Study of 131 Comatose Malawian Children QJM: An International Journal of Medicine. ,vol. 71, pp. 441- 459 ,(1989) , 10.1093/OXFORDJOURNALS.QJMED.A068338
N.J. White, K. Marsh, R.C. Turner, K.D. Miller, C.D. Berry, D.H. Williamson, J. Brown, HYPOGLYCAEMIA IN AFRICAN CHILDREN WITH SEVERE MALARIA The Lancet. ,vol. 329, pp. 708- 711 ,(1987) , 10.1016/S0140-6736(87)90354-0
Myint-Oo, Isoenzyme variation in schizonts of Plasmodium vivax from Burma Transactions of The Royal Society of Tropical Medicine and Hygiene. ,vol. 80, pp. 1- 4 ,(1986) , 10.1016/0035-9203(86)90180-X
Nicholas J. White, Sornchai Looareesuwan, David A. Warrell, Mary J. Warrell, Damnai Bunnag, Tranakchit Harinasuta, Quinine pharmacokinetics and toxicity in cerebral and uncomplicated falciparum malaria The American Journal of Medicine. ,vol. 73, pp. 564- 572 ,(1982) , 10.1016/0002-9343(82)90337-0
N. J. White, Drug treatment and prevention of malaria. European Journal of Clinical Pharmacology. ,vol. 34, pp. 1- 14 ,(1988) , 10.1007/BF01061409
E. Stahel, P. Druilhe, M. Gentilini, Antagonism of chloroquine with other antimalarials. Transactions of The Royal Society of Tropical Medicine and Hygiene. ,vol. 82, pp. 221- 221 ,(1988) , 10.1016/0035-9203(88)90417-8
A.P. Hall, Quinine and chloroquine antagonism in falciparum malaria Transactions of The Royal Society of Tropical Medicine and Hygiene. ,vol. 67, pp. 425- 425 ,(1973) , 10.1016/0035-9203(73)90131-4
S Looareesuwan, NJ White, P Chanthavanich, G Edwards, DD Nicholl, C Bunch, DA Warrell, Cardiovascular toxicity and distribution kinetics of intravenous chloroquine. British Journal of Clinical Pharmacology. ,vol. 22, pp. 31- 36 ,(1986) , 10.1111/J.1365-2125.1986.TB02876.X
Y Wattanagoon, R E Phillips, D A Warrell, K Silamut, S Looareesuwan, B Nagachinta, D J Back, Intramuscular loading dose of quinine for falciparum malaria: pharmacokinetics and toxicity. BMJ. ,vol. 293, pp. 11- 13 ,(1986) , 10.1136/BMJ.293.6538.11