Efficacy of a loading dose of oral chloroquine in a 36-hour treatment schedule for uncomplicated plasmodium falciparum malaria.

摘要: The efficacy of a loading dose 20 mg chloroquine per kg body weight os given at intervals during the first day was evaluated in 27 patients Madagascar with Plasmodium falciparum malaria. conventional regimen 25 mg/kg over 3 days (schedule 1) thus compared 30 2 2; one 10 followed by two doses 5 6-h on and 12-h second day) terms their clinical parasitological efficacies, tolerance, drug concentration-time curves. At 24 h schedule gave higher levels blood, which induced more rapid decrease parasitemia. time required for 50% initial parasitemia shorter (14.3 +/- 1.6 h) than it 1 (35.5 5.4 h; P less 0.01). Moreover, negative blood smears were obtained rapidly (50.8 3.7 (72 8.7 h). As predicted curve, no high, potentially toxic peak concentration appeared adverse effects observed 2). These findings support idea that 12 is well tolerated can be used to obtain shorten treatment uncomplicated chloroquine-susceptible malaria field.