Kinetics of the uptake and elimination of chloroquine in children with malaria.
作者： SA Adelusi , AH Dawodu , LA Salako
DOI: 10.1111/J.1365-2125.1982.TB02016.X
关键词:
摘要: 1 Ten children with Plasmodium falciparum malaria were treated 25 mg/kg chloroquine over 3 days and observed for 7 days. 2 Chloroquine was determined in the red blood cells plasma, cell/plasma concentration ratio correlated disappearance of parasites from blood. It found that this decreased remained almost steady after had disappeared completely The half-life (t1/2) elimination rate constant "terminal' slope (lambda beta) plasma log concentration-time curve estimated to be 135.9 +/- 9.92 h 0.005 0.001 h-1 (s.d.) respectively. 4 t1/2 lambda beta calculated cell not significantly different corresponding values curve.
sci-hub.se 参考文章(7)
PETER B. MACOMBER, HELMUTH SPRINZ, A. J. TOUSIMIS, Morphological Effects of Chloroquine on Plasmodium berghei in Mice Nature. ,vol. 214, pp. 937- 939 ,(1967) , 10.1038/214937A0
A. F. Tuboku-Metzger, Chemotherapy of Malaria BMJ. ,vol. 1, pp. 1378- 1378 ,(1964) , 10.1136/BMJ.1.5394.1378-A
D. C. WARHURST, D. J. HOCKLEY, Mode of action of chloroquine on Plasmodium berghei and P. cynomolgi. Nature. ,vol. 214, pp. 935- 936 ,(1967) , 10.1038/214935A0
S. A. ADELUSI, L. A. SALAKO, Improved fluorimetrie assay of chloroquine in biological samples Journal of Pharmacy and Pharmacology. ,vol. 32, pp. 711- 712 ,(2011) , 10.1111/J.2042-7158.1980.TB13045.X
A.Fadeke Aderounmu, L.A. Salako, S.A. Adelusi, Chloroquine sensitivity of Plasmodium falciparum in Ibadan, Nigeria. Transactions of The Royal Society of Tropical Medicine and Hygiene. ,vol. 74, pp. 393- 395 ,(1980) , 10.1016/0035-9203(80)90108-X
M Numata, K Murakami, K Nishikawa, S Kikuchi, Suzuoki-Ziro, Urinary metabolites of thiamine tetrahydrofurfuryl disulfide in rats. Journal of Pharmacology and Experimental Therapeutics. ,vol. 158, pp. 353- 364 ,(1967)
Marianne Frisk-Holmberg, Yngve Bergkvist, Britta Domeij-Nyberg, Laila Hellström, Folke Jansson, Chloroquine serum concentration and side effects: evidence for dose-dependent kinetics. Clinical Pharmacology & Therapeutics. ,vol. 25, pp. 345- 350 ,(1979) , 10.1002/CPT1979253345