MicroRNAs Involvement in Radioresistance of Head and Neck Cancer.
作者： Parwez Ahmad , Jiri Sana , Marek Slavik , Pavel Slampa , Pavel Smilek
DOI: 10.1155/2017/8245345
关键词: Radioresistance 、 microRNA 、 Cancer research 、 Cancer 、 Radiation therapy 、 Esophageal cancer 、 Head and neck cancer 、 Biology 、 Epithelial–mesenchymal transition 、 Oncology 、 Lung cancer 、 Internal medicine
摘要: Resistance to the ionizing radiation is a current problem in treatment and clinical management of various cancers including head neck cancer. There are several biological molecular mechanisms described be responsible for resistance tumors radiotherapy. Among them, main include alterations intracellular pathways involved DNA damage repair, apoptosis, proliferation, angiogenesis. It has been found that regulation these complex processes often controlled by microRNAs. MicroRNAs short endogenous RNA molecules posttranscriptionally modulate gene expression their deregulated observed many Specific patterns microRNAs have also shown predict prognosis therapeutic response Therefore, present promising biomarkers targets might overcome improve cancer patients. In this review, we summarize knowledge functional role radioresistance with special focus on
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