Personalized Medicine in Non–Small-Cell Lung Cancer: Is KRAS a Useful Marker in Selecting Patients for Epidermal Growth Factor Receptor–Targeted Therapy?
作者： Patrick J. Roberts , Thomas E. Stinchcombe , Channing J. Der , Mark A. Socinski
关键词: Colorectal cancer 、 Oncology 、 Internal medicine 、 Lung cancer 、 Cancer research 、 Cetuximab 、 Epidermal growth factor receptor 、 Medicine 、 Gefitinib 、 Targeted therapy 、 Personalized medicine 、 KRAS
摘要: In patients with metastatic colorectal cancer, the predictive value of KRAS mutational status in selection for treatment anti–epidermal growth factor (EGFR) monoclonal antibodies is established. non–small-cell lung cancer (NSCLC), utility determining to predict clinical benefit anti-EGFR therapies remains unclear. This review will provide a brief description Ras biology, an overview aberrant signaling NSCLC, and summarize data using as negative biomarker therapies. Retrospective investigations predictor from NSCLC have been performed; however, small samples sizes result low prevalence mutations rate tumor sample collection limited strength these analyses. Although association between presence mutation lack o...
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