Prevention of reactive oxygen-induced endothelial cell injury by blocking its process.
作者： H. Shimura , M. Yamaguchi , M. Kuzume , A. Matsumiya , T. Matsumoto
DOI: 10.1159/000008717
关键词: Calcium channel blocker 、 Bucladesine 、 Channel blocker 、 Protein kinase inhibitor 、 Internal medicine 、 Intracellular 、 Pharmacology 、 Endocrinology 、 Chemistry 、 Protein kinase A 、 Extracellular 、 Reactive oxygen species
摘要: Endothelial cell (EC) injury induced by reactive oxygen species (ROS) was investigated and effects of Ca(2+) channel blockers, agents which elevate intracellular cAMP levels ([cAMP](i)), protein kinase inhibitors on H(2)O(2)-induced EC were analyzed using human umbilical vein cultures. Exposure to H(2)O(2) increased decreased [cAMP](i). [cAMP](i)-elevating agents, significantly inhibited injury. Data suggest that is mediated extracellular influx, efflux, signaling, each blocked or inhibitors. It suggested ischemia/reperfusion ROS may be prevented
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