Importance of anaerobic bacteria in the cobalamin malabsorption of the experimental rat blind loop syndrome

摘要: Abstract Cobalamin malabsorption is a frequent occurrence in the stasis syndrome. Although exact mechanism for cobalamin has not yet been definied, present evidence supports avid uptake of cabalamin and to lesser degree, intrinsic factor-cobalamin complex by intestinal bacteria. However, correlation between quantitative cultures total overgrowth flora vivo as well vitro parameters absorption fully evaluated. Self-filling blind loops were constructed urinary excretion labeled cyanacobalamin evaluated via metabolic cages which allowed strict separation urine from feces. Blind loop rats manifested 2.4 ± 1.4% vs. 9.5 1.2% nonoperated controls, p