Klotho and the Growth Hormone/Insulin-Like Growth Factor 1 Axis: Novel Insights into Complex Interactions.

摘要: Abstract The growth hormone (GH)/insulin-like factor (IGF)-1 axis is pivotal for many metabolic functions, including proper development and of bones, skeletal muscles, adipose tissue. Defects in the axis’ activity during childhood result abnormalities, while increased secretion GH from pituitary results acromegaly. In order to keep narrow physiologic concentration, IGF-1 are tightly regulated by hypothalamic, pituitary, endocrine, paracrine, autocrine factors. Klotho was first discovered as an aging-suppressor gene. Mice that do not express klotho die prematurely with multiple symptoms aging, several them also characteristic decreased GH/IGF-1 activity. highly expressed brain, kidney, parathyroid glands, but can serve a circulating its shedding, forming soluble be detected blood, cerebrospinal fluid, urine. Several lines evidence suggest association between levels axis: GH-secreting cells anterior klotho-deficient mice hypotrophic; altered subjects pathologies axis; accumulating data indicate direct regulator secretion. Thus, seems new player intricate regulation axis.