Brain cancer mortality and potential occupational exposure to lead: Findings from the National Longitudinal Mortality Study, 1979–1989

摘要: We evaluated the association between potential occupational lead exposure and risk of brain cancer mortality in National Longitudinal Mortality Study (NLMS), which is a prospective census-based cohort study among noninstitutionalized United States population (1979-1989). The present was limited to individuals for whom occupation industry were available (n = 317,968). Estimates probability intensity assigned using job-exposure matrix (JEM). Risk estimates impact on computed standardized ratio (SMR) proportional hazards Poisson regression techniques, adjusting effects age, gender several other covariates. Brain rates greater jobs potentially involving as compared those unexposed (age- gender-adjusted hazard (HR) 1.5; 95% confidence interval (CI) 0.9-2.3) with indications an exposure-response trend (probability: low HR 0.7 (95% CI 0.2-2.2), medium 1.4 0.8-2.5), high 2.2 1.2-4.0); intensity: 1.2 0.7-2.1), medium/high 1.9 1.0-3.4)). greatest highest levels (HR 2.3; 1.3-4.2). These findings provide further support mortality, but need be interpreted cautiously due consideration one disease entity absence biological measures exposure.