作者: Meral Cetin , Ergun Pinarbasi , Ferda E. Percin , Egemen Akgun , Sibel Percin
DOI: 10.1111/J.1447-0756.2005.00281.X
关键词: Eclampsia 、 Gastroenterology 、 Glutathione S-transferase 、 Pathogenesis 、 Turkish population 、 Medicine 、 Genotype 、 Internal medicine 、 HELLP syndrome 、 Hemolysis 、 Endocrinology 、 Genetic variability
摘要: Aim: There is substantial evidence that genetic factors play a role in pre-eclampsia. The aim of this study was to determine whether variability the encoding genes for glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) contributes individual differences susceptibility pre-eclampsia, eclampsia, or hemolysis, elevated liver enzymes, low platelets (HELLP syndrome). Methods: A total 221 women with eclampsia HELLP syndrome 147 healthy female controls were genotyped GSTM1 GSTT1 polymorphisms by polymerase chain reaction (PCR). Statistical evaluation polymorphic rates carried out using χ2 analysis. Results: This included 140 pre-eclamptic, 33 eclamptic 48 cases controls. frequencies null genotype 58%, 45%, 60% syndrome, respectively, it 55%. distribution was 22%, 21%, and 27% for pre-eclampsia, eclampsia, HELLP syndrome, respectively, in controls 22%. no significant association between syndrome. Conclusion: Our data do not support pathogenesis syndrome.