No association of polymorphisms in the glutathione S-transferase genes with pre-eclampsia, eclampsia and HELLP syndrome in a Turkish population.

作者: Meral Cetin , Ergun Pinarbasi , Ferda E. Percin , Egemen Akgun , Sibel Percin

DOI: 10.1111/J.1447-0756.2005.00281.X

关键词: EclampsiaGastroenterologyGlutathione S-transferasePathogenesisTurkish populationMedicineGenotypeInternal medicineHELLP syndromeHemolysisEndocrinologyGenetic variability

摘要: Aim: There is substantial evidence that genetic factors play a role in pre-eclampsia. The aim of this study was to determine whether variability the encoding genes for glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) contributes individual differences susceptibility pre-eclampsia, eclampsia, or hemolysis, elevated liver enzymes, low platelets (HELLP syndrome). Methods: A total 221 women with eclampsia HELLP syndrome 147 healthy female controls were genotyped GSTM1 GSTT1 polymorphisms by polymerase chain reaction (PCR). Statistical evaluation polymorphic rates carried out using χ2 analysis. Results: This included 140 pre-eclamptic, 33 eclamptic 48 cases controls. frequencies null genotype 58%, 45%, 60% syndrome, respectively, it 55%. distribution was  22%,  21%,  and  27%  for  pre-eclampsia,  eclampsia,  HELLP  syndrome,  respectively,  in  controls  22%. no significant association between syndrome. Conclusion: Our data do not support pathogenesis syndrome.

参考文章(27)
Geoffrey J. Beckett, John D. Hayes, Glutathione S-transferases: biomedical applications. Advances in Clinical Chemistry. ,vol. 30, pp. 281- 380 ,(1993) , 10.1016/S0065-2423(08)60198-5
D A Grimes, R W Rochat, J M Hughes, A M Kaunitz, J C Smith, M E Kafrissen, Causes of maternal mortality in the United States Obstetrics & Gynecology. ,vol. 65, pp. 605- 612 ,(1985)
S Pemble, K R Schroeder, S R Spencer, D J Meyer, E Hallier, H M Bolt, B Ketterer, J B Taylor, Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochemical Journal. ,vol. 300, pp. 271- 276 ,(1994) , 10.1042/BJ3000271
J Seidegård, G Ekström, The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics. Environmental Health Perspectives. ,vol. 105, pp. 791- 799 ,(1997) , 10.1289/EHP.105-1470052
Hubel, Kozlov, Kagan, Evans, Davidge, McLaughlin, Roberts, Decreased transferrin and increased transferrin saturation in sera of women with preeclampsia: Implications for oxidative stress American Journal of Obstetrics and Gynecology. ,vol. 175, pp. 692- 700 ,(1996) , 10.1053/OB.1996.V175.A74252
Ariadne Malamitsi-Puchner, John Tziotis, Dimitrios Evangelopoulos, Lazaros Fountas, George Vlachos, George Creatsas, Constantine E Sekeris, Paraskevi Moutsatsou, Gene analysis of the N-terminal region of the estrogen receptor alpha in preeclampsia Steroids. ,vol. 66, pp. 695- 700 ,(2001) , 10.1016/S0039-128X(01)00101-5
Edward T. Crosby, Obstetrical anaesthesia for patients with the syndrome of haemolysis, elevated liver enzymes and low platelets. Canadian Journal of Anaesthesia-journal Canadien D Anesthesie. ,vol. 38, pp. 227- 233 ,(1991) , 10.1007/BF03008152
L HEFLER, Polymorphisms within the interleukin-1β gene cluster and preeclampsia☆ Obstetrics & Gynecology. ,vol. 97, pp. 664- 668 ,(2001) , 10.1016/S0029-7844(01)01128-0
Hannu Norppa, Genetic susceptibility, biomarker respones, and cancer. Mutation Research-reviews in Mutation Research. ,vol. 544, pp. 339- 348 ,(2003) , 10.1016/J.MRREV.2003.09.006